An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A
Enantioselective route to key intermediates in the synthesis of carbocyclic phosphoribosyltransferase transition state analogues
โ Scribed by Mohammad Ahmadian; Naveen K. Khare; James M. Riordan; Anthony E. Klon; David W. Borhani
- Book ID
- 108371400
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 246 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Di
A new route to the enantiomerically pure azetidin-2-one 3, a key intermediate for the synthesis of trinems, has been developed, incorporating enantioselective intramolecular C-H insertion of ct-methoxycarbonyl-ot-diazoacetamide catalyzed by chiral Rh(II) complexes and diastereoselective arene hydrog
Enantioselective Intramolecular C-H Insertion Route to a Key Intermediate for the Synthesis of Trinem Antibiotics. -The new route to the chiral azetidin-2-one title compound (III) is based on the Rh-catalyzed decomposition of the diazoester (I) and following intramolecular carbene C-H insertion. Th