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Enantioselective route to a key intermediate in the total synthesis of forskolin

✍ Scribed by E.J. Corey; Paul Da Silva Jardine; Tetsuya Mohri

Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
217 KB
Volume
29
Category
Article
ISSN
0040-4039

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✦ Synopsis

An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization.

A total synthesis of forskolin (1) (racemic form), a potent activator of adenylate cyclase of considerable

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