An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A
Enantioselective route to a key intermediate in the total synthesis of ginkgolide B
โ Scribed by E.J. Corey; Ashvinikumar V. Gavai
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 218 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Di
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