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A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin

✍ Scribed by E.J Corey; Paul Da Silva Jardine

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 285 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)70681-2

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✦ Synopsis

A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Diels-Alder reaction to tricyclic lacrone 9.

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