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A highly efficient route to a key intermediate for the synthesis of A prostaglandins

✍ Scribed by E.J. Corey; Paul A. Grieco

Publisher: Elsevier Science
Year: 1972
Tongue: French
Weight: 139 KB
Volume: 13
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)84252-0

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✦ Synopsis

The iodo lactone I, which has been used as a key intermediate for the synthesis of the six natural primary prostaglandins, is readily available by a synthetic process in which the average yield per step is 95% (l-4). Although the A prostaglandins can be derived from the primary E prostaglandins by dehydration

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