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A practical and efficient synthesis of the ziegler key intermediate for the synthesis of forskolin

✍ Scribed by Maria I Colombo; Carmen Somoza; Juan Zinczuk; José A Bacigaluppo; Edmundo A Rúveda

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
249 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

The Ziegler intermediate 2, previously used in three total syntheses of forskolin (1) has been synthesized efficiently from enone 3. The key transformation of this sequence is the early and stereoselective introduction of the C-6, C-7 oxygen functional groups present in the natural product.

The highly oxygenated labdane diterpene forskolin (l), isolated from the roots of the Indian herb Coleus forskohlii,' has generated an enormous amount of synthetic interest2 because of its unique structural

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