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A SIMPLIFIED ROUTE TO A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF RESERPINE

✍ Scribed by Woodward, R. B.; Bader, F. E.; Bickel, H.; Frey, A. J.; Kierstead, R. W.


Book ID
115472764
Publisher
American Chemical Society
Year
1956
Tongue
English
Weight
128 KB
Volume
78
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES


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An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A

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A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Di