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Effects of inducers and inhibitors of the benzo(a)pyrene hydroxylase of isolated rat liver nuclei and nuclear envelopes on the binding of benzo(a)pyrene to DNA

✍ Scribed by K. Alexandrov

Book ID
113145921
Publisher
Elsevier Science
Year
1977
Weight
574 KB
Volume
13
Category
Article
ISSN
0014-2964

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Rat liver microsome-mediated binding of
Rat liver microsome-mediated binding of benzo(A)pyrene metabolites to DNA
✍ M. H. Thompson; H. W. S. King; M. R. Osborne; P. Brookes πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 French βš– 422 KB πŸ‘ 1 views

## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy