## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8βdihydroβ7,8βdihydroxy
β¦ LIBER β¦
Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomes
β Scribed by K. Alexandrov; P. Brookes; H.W.S. King; M.R. Osborne; M.H. Thompson
- Book ID
- 113135595
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 910 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0009-2797
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## Abstract A rat liver microsomeβmediated bacterial mutagenicity test showed 9βhydroxybenzo (__a__) pyrene to be significantly more effective as a preβmutagen than benzo (__a__) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late ex