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Binding of metabolically activated benzo(a)pyrene to DNA and histones of rat liver, lung and regenerating liver

✍ Scribed by John M. Pezzuto; Michael A. Lea; Chung S. Yang

Book ID
118938576
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
315 KB
Volume
22
Category
Article
ISSN
0024-3205

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✍ M. H. Thompson; H. W. S. King; M. R. Osborne; P. Brookes πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 French βš– 422 KB πŸ‘ 1 views

## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy