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Discovery of Bicyclic Thymidine Analogues as Selective and High-Affinity Inhibitors of Mycobacterium tuberculosis Thymidine Monophosphate Kinase

✍ Scribed by Vanheusden, Veerle; Munier-Lehmann, Hélène; Froeyen, Matheus; Busson, Roger; Rozenski, Jef; Herdewijn, Piet; Van Calenbergh, Serge


Book ID
126130565
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
225 KB
Volume
47
Category
Article
ISSN
0022-2623

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Mycobacterium tuberculosis Thymidine Mon
✍ Philippe Van Rompaey; Koen Nauwelaerts; Veerle Vanheusden; Jef Rozenski; Hélène 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

## Abstract __Mycobacterium tuberculosis__ thymidine monophosphate kinase (TMPKmt) has recently been introduced as a potential target for the structure‐based design of anti‐tuberculosis drugs. Based on the TMPKmt X‐ray structure and previous S.A.R. studies, we synthesised the nucleoside analogues *