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A New Family of Inhibitors of Mycobacterium Tuberculosis Thymidine Monophosphate Kinase

โœ Scribed by Gasse, C.; Huteau, V.; Douguet, D.; Munier-Lehmann, H.; Pochet, S.


Book ID
120624359
Publisher
Taylor and Francis Group
Year
2007
Tongue
English
Weight
287 KB
Volume
26
Category
Article
ISSN
0732-8311

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Mycobacterium tuberculosis Thymidine Mon
โœ Philippe Vanย Rompaey; Koen Nauwelaerts; Veerle Vanheusden; Jef Rozenski; Hรฉlรจne ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 170 KB

## Abstract __Mycobacterium tuberculosis__ thymidine monophosphate kinase (TMPKmt) has recently been introduced as a potential target for the structureโ€based design of antiโ€tuberculosis drugs. Based on the TMPKmt Xโ€ray structure and previous S.A.R. studies, we synthesised the nucleoside analogues *