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Synthesis and Evaluation of Thymidine-5′-O-monophosphate Analogues as Inhibitors of Mycobacterium tuberculosis Thymidylate Kinase.

✍ Scribed by Veerle Vanheusden; Helene Munier-Lehmann; Sylvie Pochet; Piet Herdewijn; Serge Van Calenbergh


Publisher
John Wiley and Sons
Year
2003
Weight
78 KB
Volume
34
Category
Article
ISSN
0931-7597

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Mycobacterium tuberculosis Thymidine Mon
✍ Philippe Van Rompaey; Koen Nauwelaerts; Veerle Vanheusden; Jef Rozenski; Hélène 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

## Abstract __Mycobacterium tuberculosis__ thymidine monophosphate kinase (TMPKmt) has recently been introduced as a potential target for the structure‐based design of anti‐tuberculosis drugs. Based on the TMPKmt X‐ray structure and previous S.A.R. studies, we synthesised the nucleoside analogues *