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Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

✍ Scribed by Constância, Miguel; Dean, Wendy; Lopes, Susana; Moore, Tom; Kelsey, Gavin; Reik, Wolf


Book ID
109829095
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
297 KB
Volume
26
Category
Article
ISSN
1061-4036

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Several human imprinted genes have been identified and are implicated in genetic diseases and tumorigenesis. We studied alterations of two imprinted genes, the paternally imprinted H19 and maternally imprinted IGF2, in 15 ovarian tumors with various cell types. To know allele-specific expression of