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Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

✍ Scribed by Steenman, Marja J. C.; Rainier, Shirley; Dobry, Craig J.; Grundy, Paul; Horon, Isabelle L.; Feinberg, Andrew P.

Book ID
109916461
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
697 KB
Volume
7
Category
Article
ISSN
1061-4036

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## Abstract To ascertain whether __p53__ deficiency in vivo leads to the deregulation of DNA methylation machinery prior to tumor development, we investigated the expression profile of DNA methyltransferases in the thymus and the liver of __p53__^+/+^, __p53__^+/βˆ’^, and __p53__^βˆ’/βˆ’^ mice at 7 weeks