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Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome

✍ Scribed by Sparago, Angela; Cerrato, Flavia; Vernucci, Maria; Ferrero, Giovanni Battista; Silengo, Margherita Cirillo; Riccio, Andrea


Book ID
109919033
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
377 KB
Volume
36
Category
Article
ISSN
1061-4036

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Several human imprinted genes have been identified and are implicated in genetic diseases and tumorigenesis. We studied alterations of two imprinted genes, the paternally imprinted H19 and maternally imprinted IGF2, in 15 ovarian tumors with various cell types. To know allele-specific expression of