Several human imprinted genes have been identified and are implicated in genetic diseases and tumorigenesis. We studied alterations of two imprinted genes, the paternally imprinted H19 and maternally imprinted IGF2, in 15 ovarian tumors with various cell types. To know allele-specific expression of
Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma
β Scribed by El-Naggar, Adel K; Lai, Syeling; Tucker, Susan A; Clayman, Gary L; Goepfert, Helmuth; Hong, Waun Ki; Huff, Vicki
- Book ID
- 110062555
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 210 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract ## Background Niban was initially identified in the Eker rat, a model of renal carcinogenesis. We examined Niban expression in head and neck squamous cell carcinoma (HNSCC) and head and neck dysplastic lesions. ## Methods Using a polyclonal rabbit antiβhuman Niban antibody, 43 cases
## Abstract ## Background __IGF2__ and __H19__ are reciprocal imprinted genes with paternal and maternal monoallelic expression, respectively. This is interesting, because __IGF2__ is known as a growth factor, and __H19__ encodes a RNA with putative tumor suppressor action. Furthermore, __IGF2__ a
Background. Loss of heterozygosity (LOH) studies have been pivotal in identifying tumor suppressor genes involved in the pathogenesis of a number of cancers. In squamous cell carcinomas of the head and neck region (SCCHN), LOH studies using the Southern blot technique are scarce. Methods. SCCHNs we