✦ LIBER ✦

Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia

✍ Scribed by Shin Ito; Hiroaki Fujii; Toshiharu Matsumoto; Masaaki Abe; Katsuhisa Ikeda; Okio Hino

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 305 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21153

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Niban was initially identified in the Eker rat, a model of renal carcinogenesis. We examined Niban expression in head and neck squamous cell carcinoma (HNSCC) and head and neck dysplastic lesions.

Methods

Using a polyclonal rabbit anti‐human Niban antibody, 43 cases of HNSCC and 30 cases of head and neck squamous dysplasia were immuonohistochemically stained for Niban. Ancillary genetic studies were also performed.

Results

Forty‐two of 43 HNSCCs (97.6%) and 20 of 30 (66.6%) dysplastic lesions were positively stained for Niban. The staining was generally less intense in cases of dysplasia than HNSCC. Three of 8 normal mucosal samples from drinker/smokers also showed weak Niban expression. Normal head and neck squamous epithelium from nondrinker/nonsmokers did not stained for Niban. Reverse transcription polymerase chain reaction results matched the immuonohistochemical results.

Conclusion

The expression of Niban frequently begins in the early stages of head and neck squamous carcinoma and remains upregulated throughout the carcinogenic process. Niban may be a good molecular marker of HNSCC. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

📜 SIMILAR VOLUMES

Head and neck squamous cell carcinoma in

Head and neck squamous cell carcinoma in childhood

✍ de Carvalho, Marcos Brasilino; Sobrinho, Josias de Andrade; Rapoport, Abrão; Fav 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 2 views

## Background: Squamous cell carcinoma (scc) of the head and neck region is rare in young patients and even less frequent in children 15 years or younger children. the patients reported in the literature are isolated cases and their management is always difficult because there is no large experienc

Expression of cancer testis antigens in

Expression of cancer testis antigens in head and neck squamous cell carcinomas

✍ David L. A. Figueiredo; Rui C. M. Mamede; Rodrigo Proto-Siqueira; Luciano Neder; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

## Abstract ## Background. There is considerable interest in the expression of cancer testis (CT) antigens in human cancers, because they may serve as the basis for diagnostic tests or an immunologic approach to therapy, or as prognostic markers. ## Methods. On this basis, we evaluated by semiqu

Role of squamous cell carcinoma antigen

Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma

✍ Torahiko Nakashima; Ryuji Yasumatsu; Yuichiro Kuratomi; Muneyuki Masuda; Takashi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB 👁 2 views

## Background: Serine proteases have important roles in tumor invasion and metastasis, and their inhibitors, serine protease inhibitors (serpins), are attractive targets for therapeutic strategies. on chromosome 18q21, there is a cluster of serpins: maspin, headpin, and squamous cell carcinoma anti

Head and neck squamous cell carcinoma in

Head and neck squamous cell carcinoma in FAMMM syndrome

✍ Vladimir Vinarsky; Robert L. Fine; Adel Assaad; Ying Qian; John A. Chabot; Glori 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 364 KB 👁 2 views

## Abstract ## Background Germline mutations at the __INK4a/p16__ locus are implicated in several human cancer syndromes, including familial atypical multiple mole melanoma (FAMMM) syndrome, FAMMM‐pancreatic cancer (FAMMM‐PC) syndrome, and in familial head and neck cancer syndrome. ## Methods We

MicroRNA alterations in head and neck sq

MicroRNA alterations in head and neck squamous cell carcinoma

✍ Steven S. Chang; Wei Wen Jiang; Ian Smith; Luana M. Poeta; Shahnaz Begum; Chad G 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 244 KB 👁 1 views

## Abstract MicroRNAs (mirs) are small noncoding RNA molecules (∼22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we

Gene expression profiling in head and ne

Gene expression profiling in head and neck squamous cell carcinoma: Clinical perspectives

✍ Benjamin Lallemant; Alexandre Evrard; Guillaume Chambon; Omar Sabra; Sophie Kach 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 108 KB 👁 2 views

## Abstract ## __Background.__ To date, more than 60 gene expression profiling (GEP) studies have been published in the field of head and neck squamous cell carcinoma (HNSCC) with variable objectives, methods, and results. ## __Methods.__ The purpose of this study was to present a state‐of‐the‐a