Coumermycin a1—biopharmaceutical studies II
✍ Scribed by Harold L. Newmark; Julius Berger; J. Thurø Carstensen
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 295 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A concise synthesis of the antibiotic coumermycin A 1 , a natural product isolated from streptomyces, was achieved. In a key step, a selectively protected noviose sugar was prepared from novobiocin through a transglycosylation reaction with acetone.
The binding ratio of taurinophenetidine or nicotinoyltaurinophenetidine with serum protein in rabbits varies according to experimental conditions in dialysis, but the averaged binding ratios of taurinophenetidine and its nicotinate were roughly 40- 50z at high doses. Taurinophenetidine and its nicot
The pharmacokinetic profile of coumermycin A1 has been determined in man following intravenous and oral administration. The antibiotic is eliminated slowly from the bloodstream and appears to be highly biotransformed. The plasma level versus time curve after intravenous injection is consistent with