๐”– Bobbio Scriptorium
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Synthesis of Coumermycin A1.

โœ Scribed by Steven H. Olson; Llnon H. Slossberg


Publisher
John Wiley and Sons
Year
2003
Weight
72 KB
Volume
34
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of coumermycin A1
โœ Steven H Olson; Llnon H Slossberg ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 171 KB

A concise synthesis of the antibiotic coumermycin A 1 , a natural product isolated from streptomyces, was achieved. In a key step, a selectively protected noviose sugar was prepared from novobiocin through a transglycosylation reaction with acetone.

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The pharmacokinetic profile of coumermycin A1 has been determined in man following intravenous and oral administration. The antibiotic is eliminated slowly from the bloodstream and appears to be highly biotransformed. The plasma level versus time curve after intravenous injection is consistent with

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Synthesis of (.+-.)-Phloeodictine A1.
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