Coumermycin a1—biopharmaceutical studies I
✍ Scribed by Harold L. Newmark; Julius Berger
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 348 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
A concise synthesis of the antibiotic coumermycin A 1 , a natural product isolated from streptomyces, was achieved. In a key step, a selectively protected noviose sugar was prepared from novobiocin through a transglycosylation reaction with acetone.
The pharmacokinetic profile of coumermycin A1 has been determined in man following intravenous and oral administration. The antibiotic is eliminated slowly from the bloodstream and appears to be highly biotransformed. The plasma level versus time curve after intravenous injection is consistent with
Blood levels of 4-(aminoethanesulfonylamino)antipyrine in rabbits were determined, and binding of the chemical with rabbit serum in uiuo and in uitro was examined. Metabolites of the chemical in rabbit urine were separated into five compounds: rubazonic acid (trace), Caminoantipyrine, 4-acetylaminoa