Biopharmaceutical studies on 4-(aminoethanesulfonylamino)antipyrine and related compounds I

✍ Scribed by Shun-Ichi Naito; Yasuko Ueno; Hisashi Yamaguchi; Toshio Nakai

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 606 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600218

✦ Synopsis

Blood levels of 4-(aminoethanesulfonylamino)antipyrine in rabbits were determined, and binding of the chemical with rabbit serum in uiuo and in uitro was examined. Metabolites of the chemical in rabbit urine were separated into five compounds: rubazonic acid (trace), Caminoantipyrine, 4-acetylaminoantipyrine, 4-hydroxyantipyrine (trace), and unchanged chemical. Glucuronide in urine of rabbits administered with 4-(aminoethane-sulfony1amino)antipyrine is the conjugated form with Chydroxyantipyrine. Some pharmacological activities were investigated; it was observed that the chemical shows analgesic, anti-inflammatory, antihistaminic, and antipyretic actions.

Keyphrases 0 4-(Aminoethanesulfonylamino)antipyrine-biopharmaceutical studies 0 Taurinopyrine-rabbit serum protein binding Metabolites, taurinopyrine, aminopyrine in urineseparation, analysis 0 Pharmacological screening-taurinopyrine