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Biopharmaceutical studies on aminoethanesulfonylphenetidine and related compounds II

โœ Scribed by Shun-Ichi Naito; Kazuo Fukui

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
864 KB
Volume
60
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The binding ratio of taurinophenetidine or nicotinoyltaurinophenetidine with serum protein in rabbits varies according to experimental conditions in dialysis, but the averaged binding ratios of taurinophenetidine and its nicotinate were roughly 40- 50z at high doses. Taurinophenetidine and its nicotinate are scarcely excreted in rat feces and in rat and rabbit bile. The amount of both compounds distributed in organs of mice and rats is very small. It was observed that taurinophenetidine has some analgesic and antipyretic activities, and nicotinoyltaurinophenetidine reveals some analgesic and anti-inflammatory activities but no antipyretic action.

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Biopharmaceutical studies on 4-(aminoethanesulfonylamino)antipyrine and related compounds I
โœ Shun-Ichi Naito; Yasuko Ueno; Hisashi Yamaguchi; Toshio Nakai ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 606 KB

Blood levels of 4-(aminoethanesulfonylamino)antipyrine in rabbits were determined, and binding of the chemical with rabbit serum in uiuo and in uitro was examined. Metabolites of the chemical in rabbit urine were separated into five compounds: rubazonic acid (trace), Caminoantipyrine, 4-acetylaminoa