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Synthesis of coumermycin A1

✍ Scribed by Steven H Olson; Llnon H Slossberg

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 171 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02487-5

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✦ Synopsis

A concise synthesis of the antibiotic coumermycin A 1 , a natural product isolated from streptomyces, was achieved. In a key step, a selectively protected noviose sugar was prepared from novobiocin through a transglycosylation reaction with acetone.

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