✍ Scribed by Stanley A. Kaplan
No coin nor oath required. For personal study only.
The pharmacokinetic profile of coumermycin A1 has been determined in man following intravenous and oral administration. The antibiotic is eliminated slowly from the bloodstream and appears to be highly biotransformed. The plasma level versus time curve after intravenous injection is consistent with a twocompartment open system containing a primary compartment with a volume equivalent to the volume of plasma water. The design of a pharmacokinetic model is discussed. Keyphrases 0 Coumermycin A1-pharmacokinetic profile 0 Absorption, elimination-coumermycin A1 Model, two-compartment open-coumermycin A1 0 Kinetic equations-coumermycin Al absorption, elimination
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A concise synthesis of the antibiotic coumermycin A 1 , a natural product isolated from streptomyces, was achieved. In a key step, a selectively protected noviose sugar was prepared from novobiocin through a transglycosylation reaction with acetone.