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Controlled synthesis of labelled 3-L-chlorotyrosine-[ring-13C6] and of 3,5-L-dichlorotyrosine-[ring-13C6]

✍ Scribed by Pietro Allevi; Paola Olivero; Mario Anastasia

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
137 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Pure 3-l-chlorotyrosine-[ring-13 C 6 ] is prepared by chlorination of the 5-oxazolidinone of l-tyrosine-[ring-13 C 6 ] with SO 2 Cl 2 in CH 3 COOH-Et 2 O and successive one-pot regeneration of the protected aminoacidic functions by BCl 3 in dichloromethane.

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