𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of ring-14C-labelled 4(3′-, 6′-dimethyl-3′-heptyl)-phenol

✍ Scribed by J. O. Lalah; D. Lenoir; B. Henkelmann; N. Hertkorn; K. Günther; K.-W. Schramm; A. Kettrup

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
79 KB
Volume
44
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Ring‐^14^C‐labelled 4(3′‐, 6′‐, dimethyl‐3′‐,heptyl)‐phenol (NP), an isomer of paranonyl phenol was synthesized for use in aquatic toxicity and metabolism studies. A very efficient method involving alkylation of ring‐^14^C‐labelled anisole and tertiary alkyl bromide (3‐bromo‐3,6‐dimethyl heptane) with AlCl~3~ followed by cleavage of the resultant ether with BBr~3~ was used giving a 24% yield ring labelled ^14^C‐NP (specific activity: 16.205 MBq/mg and purity >95% by HPLC) after TLC separation. Copyright © 2001 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis of 14C-labelled 6-hydroxy-5,7-
Synthesis of 14C-labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)benzothiazole dihydrochloride (14C-E3040 dihydrochloride)
✍ Shigeki Hibi; Hirotoshi Numata; Yasushi Okamoto; Osamu Takenaka; Mannen Mishima 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 113 KB

14C-Labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)benzothiazole dihydrochloride (14C-E3040 dihydrochloride), required for a study of the phrmacokinetic profile of E3040, a novel dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase, was synthesized in one step using [2-

Synthesis of 14C- and 3H-labelled 1,6–di
Synthesis of 14C- and 3H-labelled 1,6–dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomo-pyrimidazole salts
✍ D. Bánfi; J. Volford; Z. Mészáros 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 339 KB

## Abstract For pharmacological investigations tetrahydrohomopyrimidazole salts were synthetized which were labelled by ^14^C and ^3^H isotopes in definite positions. The 1‐methyl‐^14^C, carbonyl‐^14^C, 3‐carbethoxyethyl‐^14^C, 1‐methyl‐^3^H 6,7,8,9‐^3^H and 3‐carbethoxyethyl‐^3^H‐homopyrimidazole

The synthesis of serotonin 14C-labelled
The synthesis of serotonin 14C-labelled in the ring (5-hydroxytryptamine-3-14C)
✍ D. Keglevič; L. Stančič 📂 Article 📅 1967 🏛 John Wiley and Sons 🌐 French ⚖ 289 KB

For metabolic studies in this Laboratory, 5-hydroxytryptamine (serotonin) labelled with I4C in the pyrrole part of the indole ring was required. Previous attempts to reach this compound through Madelung cyclization of 3-benzyloxy--6-formylaminotoluene failed (I), although this way proved to be succe

Synthesis of 14C- and 14C3-labelled Org
Synthesis of 14C- and 14C3-labelled Org 37462
✍ P. H. G. Wiegerinck; L. W. H. Hofstede; F. M. G. M. Sperling; J. F. Vader 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract Org 37462 (1) is the active ingredient in Orgalutran^®^, an innovative product that reduces the time of treatment in __in vitro__ fertilization from four to less than two weeks. Org 37462 is a synthetic decapeptide containing several amino acids that are unnatural in stereochemistry and