## Abstract 1,4‐Dihydro‐1‐methoxy‐6,7‐methylenedioxy‐4‐oxoquinoline‐3‐carboxylic acid (I) (AB‐206), a new synthetic antimicrobial agent, was labelled with carbon‐14 at C‐3 position of the quinolinone ring for metabolic studies. The synthesis was achieved according to the reaction schemes shown in F
Synthesis of 14C- and 3H-labelled 1,6–dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomo-pyrimidazole salts
✍ Scribed by D. Bánfi; J. Volford; Z. Mészáros
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 339 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
For pharmacological investigations tetrahydrohomopyrimidazole salts were synthetized which were labelled by ^14^C and ^3^H isotopes in definite positions. The 1‐methyl‐^14^C, carbonyl‐^14^C, 3‐carbethoxyethyl‐^14^C, 1‐methyl‐^3^H 6,7,8,9‐^3^H and 3‐carbethoxyethyl‐^3^H‐homopyrimidazole isotope isomers were prepared.
📜 SIMILAR VOLUMES
We have synthesized 14C-and 2H-labeled 1,3-dihydro-3,3dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H\_-indol-2one (LY195115), an extremely potent, orally-effective cardiotonic with inotropic and vasodilator activities. '\*C-label was introduced in the antepenultimate step by reaction of a B-
## Abstract Reaction of isonicotinic [^14^C] acid hydrazide (**1**) with the Zinke salt (**2**) afforded N‐(4‐pyridyl [^14^C] carbonylimino)pyridinium ylide (**3**) in 81% chemical yield. Sodium borohydride reduction of **3** gave N‐(4‐pyridyl [^14^C] carbonylamino) −1,2,3,6‐tetrahydropyridine (**4
## Abstract The title compound 4‐(N‐acetylamino) phenyl‐1‐[^14^C] retinoate (3) was synthesized by a 2‐step sequence. Carboxyl‐[^14^C] vitamin A (1) was treated with ethylchloroformate to form the mixed anhydride (2). Treatment with acetamidophenol and heating with a catalytical amount of 4‐dimethy