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Synthesis of 2E, 4E, 8E - nonatetraenoic acid-3, 7-dimethyl-1-[14C]-9-(2′, 6′, 6′-trimethylcyclohex-1-enyl)-4-(N-acetamino) phenylester

✍ Scribed by Ute J. Haynes; J. E. Swigor

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
134 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The title compound 4‐(N‐acetylamino) phenyl‐1‐[^14^C] retinoate (3) was synthesized by a 2‐step sequence. Carboxyl‐[^14^C] vitamin A (1) was treated with ethylchloroformate to form the mixed anhydride (2). Treatment with acetamidophenol and heating with a catalytical amount of 4‐dimethylaminopyridine produced 4‐(N‐acetylamino)phenyl‐1‐[^14^C] retinoate (3) with a specific activity of 23.4 μCi/mg and a radiochemical purity of 97.2% in an overall yield of 42%.

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