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An efficient synthesis of [13C6]-3,5-dichloroaniline

✍ Scribed by Bachir Latli; Matt Hrapchak; Dhileepkumar Krishnamurthy; Chris H. Senanayake

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
122 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3,5‐Dichloroaniline is commonly found in many compounds with pharmacological and other biological activities. [^13^C~6~]‐Aniline or its hydrochloride salt was converted in three steps to [^13^C~6~]‐3,5‐dichloroaniline, which can be incorporated in compounds of interest and used as internal standards in drug metabolism and pharmacokinetics (DMPK) studies. Copyright © 2008 John Wiley & Sons, Ltd.

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