Constitutional relaxation of insulin–like growth factor II gene imprinting associated with Wilms' tumour and gigantism
✍ Scribed by Ogawa, Osamu; Becroft, David M.; Morison, Ian M.; Eccles, Michael R.; Skeen, Jane E.; Mauger, David C.; Reeve, Anthony E.
- Book ID
- 109918841
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 509 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1061-4036
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In this study messenger ribonucleic acid (mRNA) and DNA of five Wilms tumours were investigated. As expected, the level of insulin-like growth factor (IGF) II-mRNA was elevated up to 50 times in tumour tissue as compared to normal adjacent kidney tissue. In addition, genomic DNA was isolated and dig
Paternal allele-specific expression is identified for the insulinlike growth factor 2 (IGFZ) gene. Relaxation or loss of IGFZ imprinting, however, has been reported in several neoplasms. We studied the expression of IGFZ mRNA in 35 s q w m w s cancers of the esophagus and searched for the presence