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Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor

✍ Scribed by Xu, YongQin; Grundy, Paul; Polychronakos, Constantin

Book ID
110060567
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
491 KB
Volume
14
Category
Article
ISSN
0950-9232

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## Abstract The most common known molecular defect in Wilms tumor (WT) of the kidney, the most frequent solid tumor of childhood, is loss of imprinting (LOI) of the insulin‐like growth factor–II gene (__IGF2__), which involves activation of the normally silent maternal allele of the gene and hyperm