Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
β Scribed by Ogawa, Osamu; Eccles, Michael R.; Szeto, Jenny; McNoe, Leslie A.; Yun, Kankatsu; Maw, Marion A.; Smith, Peter J.; Reeve, Anthony E.
- Book ID
- 109783980
- Publisher
- Nature Publishing Group
- Year
- 1993
- Tongue
- English
- Weight
- 360 KB
- Volume
- 362
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/362749a0
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In this study messenger ribonucleic acid (mRNA) and DNA of five Wilms tumours were investigated. As expected, the level of insulin-like growth factor (IGF) II-mRNA was elevated up to 50 times in tumour tissue as compared to normal adjacent kidney tissue. In addition, genomic DNA was isolated and dig
Paternal allele-specific expression is identified for the insulinlike growth factor 2 (IGFZ) gene. Relaxation or loss of IGFZ imprinting, however, has been reported in several neoplasms. We studied the expression of IGFZ mRNA in 35 s q w m w s cancers of the esophagus and searched for the presence