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Relaxation of insulin-like growth factor 2 gene imprinting in esophageal cancer

✍ Scribed by Masaki Mori; Hiroshi Inoue; Takeshi Shiraishi; Koshi Mimori; Kenji Shibuta; Hideaki Nakashima; Kenichi Mafune; Youichi Tanaka; Hiroaki Ueo; Graham F. Barnard; Keizo Sugimachi; Tsuyoshi Akiyoshi

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 566 KB
Volume: 68
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19961115)68:4<441::aid-ijc7>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

Paternal allele-specific expression is identified for the insulinlike growth factor 2 (IGFZ) gene. Relaxation or loss of IGFZ imprinting, however, has been reported in several neoplasms.

We studied the expression of IGFZ mRNA in 35 s q w m w s cancers of the esophagus and searched for the presence or absence of relaxation of IGFZ imprinting. In 28 (80%) cases, IGFZ mRNA was overexpressed in the tumor tissues 0 compared to the normal tissues (N). The patients whose tumor invaded the adventitia showed a higher T/N ratio than those whose tumor was restricted to the musculi propria layer. Heterozygos*ty was determined by using the Apa I polymorphism in exon 9. Thirteen of 35 cases showed heterozygosity. In these 13 cases, a similar analysis was performed on cDNA obtained by reverse transcriptase-polymerase chain reaction. Consequently, 7 cases disclosed relaxation of IGFZ imprinting in the tumor tissue. The cases of esophageal cancer with relaxation of IGFZ imprinting showed a higher T/N ratio and deeper invasion than those without relaxation. The results suggest that overexpression of IGFZ mRNA plays an important role in esophageal cancer and, in certain cases, is associated with relaxation of IGFZ imprinting.

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