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Insulin-like growth factor type I receptor gene expression and obesity in esophageal adenocarcinoma

✍ Scribed by Ronghua Zhao; Kimberley Macdonald; Alan G. Casson

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
84 KB
Volume
48
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

The objective of this exploratory study was to evaluate the role of the insulin‐like growth factor I receptor (IGF‐IR) in esophageal adenocarcinoma (EADC). Using quantitative PCR, we studied IGF‐IR mRNA expression in 52 well‐characterized surgically resected EADC and matched histologically normal esophageal tissues, and examined IGF‐IR expression levels in relation to clinicopathologic characteristics, body mass index (BMI), and the common IGF‐IR polymorphism (G1013A), recently proposed to modify risk of obesity for EADC. Expression levels of IGF‐IR mRNA were not significantly different between EADC and matched histologically normal esophageal epithelia. Although no significant associations were found between IGF‐IR expression and BMI, tumor differentiation, stage or survival, when stratified by genotype, patients with the polymorphic A variant had significantly higher IGF‐IR expression in EADC tissues compared with matched normal epithelia. These findings suggest that G1013A most likely modulates IGF‐IR function, possibly by influencing gene transcription or mRNA stability, and represents a plausible mechanistic link underlying the association between obesity and esophageal malignancy. © 2009 Wiley‐Liss, Inc.

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