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Expression and imprinting of the insulin-like growth factor II gene in neonatal mouse cerebellum

✍ Scribed by Steven W. Hetts; Kenneth M. Rosen; Pieter Dikkes; Lydia Villa-Komaroff; Robin L. Mozell

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
103 KB
Volume
50
Category
Article
ISSN
0360-4012

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✦ Synopsis

Insulin-like growth factor II (IGF-II) plays significant roles in the growth and development of mammals through the regulation of mitogenesis and cell survival. Previously, IGF-II mRNA transcripts within the CNS were detected in the choroid plexus and leptomeninges (DeChiara et al., 1991). The objective of this study was to determine the expression pattern of IGF-II mRNA in different cell types of the cerebellum during development. We report here that the IGF-II gene is transcribed in granule and glial cells within the cerebellar parenchyma at various times during the early postnatal period in mice. IGF-II gene expression is further regulated by parent-specific imprinting such that only the paternal IGF-II allele is expressed in granule cells. In contrast, choroid plexus and leptomeninges express IGF-II mRNAs biallelically, indicating that cell type-specific regulation of genomic imprinting occurs within the mammalian CNS.

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