ChemInform Abstract: Asymmetric Synthesis of Unsaturated Pipecolic Acid Derivatives.

✍ Scribed by C. AGAMI; D. BIHAN; R. MORGENTIN; C. PUCHOT-KADOURI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199746210

✦ Synopsis

The synthesis of two enantiopure pipecolic acid esters (VI) and (XIII) is reported. Key steps are the intramolecular addition of allyl silane on an iminium double bond, generated via reaction of chiral β-amino alcohols (I) and (VII), with glyoxal (II).