ChemInform Abstract: Enantioselective Synthesis of Substituted Pipecolic Acid Derivatives.
โ Scribed by J. BARLUENGA; F. AZNAR; C. VALDES; C. RIBAS
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 40 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Addition of a propargylsilane moiety onto chiral cyclic of an allenic amino acid in the acyclic series; however, this isomerization did not take place with the cyclic ฮฑ-amino ester iminium ions occurs with a high level of stereoselectivity intermolecularly as well as intramolecularly. This operation
The synthesis of two enantiopure pipecolic acid esters (VI) and (XIII) is reported. Key steps are the intramolecular addition of allyl silane on an iminium double bond, generated via reaction of chiral ฮฒ-amino alcohols (I) and (VII), with glyoxal (II).