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Asymmetric Syntheses of Enantiopure 4-Substituted Pipecolic Acid Derivatives

✍ Scribed by Claude Agami; Fabrice Bisaro; Sébastien Comesse; Sébastien Guesné; Catherine Kadouri-Puchot; Rémy Morgentin


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
263 KB
Volume
2001
Category
Article
ISSN
1434-193X

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The synthesis of two enantiopure pipecolic acid esters (VI) and (XIII) is reported. Key steps are the intramolecular addition of allyl silane on an iminium double bond, generated via reaction of chiral β-amino alcohols (I) and (VII), with glyoxal (II).

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