Asymmetric Syntheses of Enantiopure 4-Substituted Pipecolic Acid Derivatives
✍ Scribed by Claude Agami; Fabrice Bisaro; Sébastien Comesse; Sébastien Guesné; Catherine Kadouri-Puchot; Rémy Morgentin
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 263 KB
- Volume
- 2001
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
The synthesis of two enantiopure pipecolic acid esters (VI) and (XIII) is reported. Key steps are the intramolecular addition of allyl silane on an iminium double bond, generated via reaction of chiral β-amino alcohols (I) and (VII), with glyoxal (II).
Synthesis of Enantiopure Functionalized Pipecolic Acids via Amino Acid Derived N-Acyliminium Ions. -N-Acyliminium ion cyclization of various non-natural olefinic amino acids (VII), (X), (XV), and (XX) in the presence of nucleophiles affords enantiopure functionalized pipecolic acids in moderate yie