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Synthesis of Enantiopure Functionalized Pipecolic Acids via Amino Acid Derived N-Acyliminium Ions

โœ Scribed by Floris P. J. T. Rutjes; Johan J. N. Veerman; Wim J. N. Meester; Henk Hiemstra; Hans E. Schoemaker


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
352 KB
Volume
1999
Category
Article
ISSN
1434-193X

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## Abstract The phenylalanine aminomutase (PAM) from __Taxus chinensis__ catalyses the conversion of ฮฑโ€phenylalanine to ฮฒโ€phenylalanine, an important step in the biosynthesis of the __N__โ€benzoyl phenylisoserinoyl sideโ€chain of the anticancer drug taxol. Mechanistic studies on PAM have suggested th