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Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer

โœ Scribed by Marie Plourde; Carolle Samson; Francine Durocher; Olga Sinilnokova; Jacques Simard


Book ID
116698127
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
1015 KB
Volume
109
Category
Article
ISSN
0960-0760

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## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of highโ€risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately twoโ€thirds of the multiple cases fa