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Genetic sequence variations andADPRThaplotype analysis in French Canadian families with high risk of breast cancer

✍ Scribed by Francine Durocher; Yvan Labrie; Geneviève Ouellette; INHERIT BRCAs; Jacques Simard


Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
482 KB
Volume
52
Category
Article
ISSN
1435-232X

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## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa