Molecular and genealogical characterization of the R1443XBRCA1mutation in high-risk French-Canadian breast/ovarian cancer families
✍ Scribed by Hélène Vézina; Francine Durocher; Martine Dumont; Louis Houde; Csilla Szabo; Martine Tranchant; Jocelyne Chiquette; Marie Plante; Rachel Laframboise; Jean Lépine; Heli Nevanlinna; Dominique Stoppa-Lyonnet; David Goldgar; Peter Bridge; Jacques Simard
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 688 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0340-6717
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## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa
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