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Variations in theNBN/NBS1gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer

✍ Scribed by Sylvie Desjardins; Joly Charles Beauparlant; Yvan Labrie; Geneviève Ouellette; INHERIT BRCAs; Francine Durocher


Book ID
115011584
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
885 KB
Volume
9
Category
Article
ISSN
1471-2407

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## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa