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Evaluation of the Contribution of the Three Breast Cancer Susceptibility Genes CHEK2 , STK11 , and PALB2 in Non- BRCA1/2 French Canadian Families with High Risk of Breast Cancer

✍ Scribed by Guénard, Frédéric; Pedneault, Christopher St-Laurent; Ouellette, Geneviève; Labrie, Yvan; Simard, Jacques; Durocher, Francine

Book ID
120197215
Publisher
Mary Ann Liebert
Year
2010
Tongue
English
Weight
432 KB
Volume
14
Category
Article
ISSN
1945-0265

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✍ Sylvie Desjardins; Pascal Belleau; Yvan Labrie; Geneviève Ouellette; Paul Besset 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 214 KB 👁 1 views

## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa