Polymorphic variations in the FANCA gene in high-risk non-BRCA1/2 breast cancer individuals from the French Canadian population
✍ Scribed by Litim, Nadhir; Labrie, Yvan; Desjardins, Sylvie; Ouellette, Geneviève; Plourde, Karine; Belleau, Pascal; Durocher, Francine
- Book ID
- 121712013
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2012
- Tongue
- English
- Weight
- 737 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1574-7891
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## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa
About 5-10% of breast cancer cases are hereditary and attributable to mutations in several susceptibility genes from which to date only 2 have been identified: BRCA1 (17q21) and BRCA2 (13q12). However, the BRCA genes only explain about 30% of familial breast/ovarian cancer, suggesting the existence