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Block synthesis of oligonucleotides by the phosphotriester approach

✍ Scribed by N.J. Cusack; C.B. Reese; J.H. van Boom

Publisher
Elsevier Science
Year
1973
Tongue
French
Weight
261 KB
Volume
14
Category
Article
ISSN
0040-4039

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✦ Synopsis

Most of the published work on the chemical synthesis of oligonucleotides* has involved the us8 of intermediates with unprotected lnternucleotide phosphodiester linkages. Such intermediates can usually be isolated only on a comparatively small scale and are sometimes difficult to obtain pure. Furthermore, the presence of free phosphodieeter functions can lead to undesirable eidereactions during subeequent phosphorylation steps. This presumably accounts for the low yields, especially of larger oligomers, often obtained by this approach.

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