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Highly reactive condensing agents for the synthesis of oligonucleotides by the phosphotriester approach

✍ Scribed by Kevin G. Devine; Colin B. Reese

Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 300 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)85258-2

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✦ Synopsis

4,6-Dinitro-l-(mesitylene-2-sulphonyloxy)-benzotriazole [DMBT, (@)I, l-(mesitylene-2-sulphonyloxy)-4-nitro-6-trifluoromethylbenzotriazole (@) and 1-(mesitylene-2-sulphonyl)-4nitro-1,2,3-triazole [iso-MSNT, (211 are more reactive condensing agents in the phosphotriester approach to oligonucleotide synthesis than 1-(mesitylene-2-sulphonylj-3-nitro-1,2,4triaaole [MSNT, (&)I by factors of at least 10, ~a. 4 and ~a. 1.3, respectively.

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