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ChemInform Abstract: The Prooligonucleotide Approach: Synthesis of Mixed SATE-phosphotriester Phosphodiester Oligonucleotides

✍ Scribed by J.-C. Bologna; G. Tosquellas; F. Morvan; B. Rayner; J.-L. Imbach


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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The Prooligonucleotide Approach: Synthes
✍ Jean-Charles Bologna; FranΓ§ois Morvan; Jean-Louis Imbach πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 232 KB πŸ‘ 1 views

The synthesis of mixed SATE-phosphotriester and phospho-linkages to yield thiono-or oxo-triester SATE and thiono-or oxo-diester linkages. This approach allows the synthesis of diester prooligonucleotides using both phosphoramidite and H-phosphonate chemistries is described. The key step is the any d