ChemInform Abstract: The Prooligonucleotide Approach: Synthesis of Mixed SATE-phosphotriester Phosphodiester Oligonucleotides
β Scribed by J.-C. Bologna; G. Tosquellas; F. Morvan; B. Rayner; J.-L. Imbach
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
The synthesis of mixed SATE-phosphotriester and phospho-linkages to yield thiono-or oxo-triester SATE and thiono-or oxo-diester linkages. This approach allows the synthesis of diester prooligonucleotides using both phosphoramidite and H-phosphonate chemistries is described. The key step is the any d