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The Prooligonucleotide Approach: Synthesis of Mixed Phosphodiester and SATE Phosphotriester Prooligonucleotides Using H-Phosphonate and Phosphoramidite Chemistries

✍ Scribed by Jean-Charles Bologna; François Morvan; Jean-Louis Imbach

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 232 KB
Volume: 1999
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199909)1999:9<2353::aid-ejoc2353>3.0.co;2-z

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✦ Synopsis

The synthesis of mixed SATE-phosphotriester and phospho-linkages to yield thiono-or oxo-triester SATE and thiono-or oxo-diester linkages. This approach allows the synthesis of diester prooligonucleotides using both phosphoramidite and H-phosphonate chemistries is described. The key step is the any desired mixed prooligos bearing either tBu-or Me-SATE enzymolabile protecting groups. selective oxidation of phosphite triester and H-phosphonate ance between lipophilicity

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